**Bohr effect**

Etymology: Christian Bohr, Danish physiologist, 1855-1911

the effect of CO2 and H+ on the affinity of hemoglobin for molecular O2. Increasing PCO2 and H+ decrease oxyhemoglobin saturation, whereas decreasing concentrations have the opposite effect. In humans a decrease of pH from 7.4 to 7.3 at 40 mm Hg PO2 decreases oxyhemoglobin saturation by 6%. The Bohr effect is particularly significant in the capillaries of working muscles and the myocardium and in maternal and fetal exchange vessels of the placenta.

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